Bodywide ecological interventions on cancer

30 janvier 2023

Published in Nature Medicine

Guido Kroemer, Jennifer L. McQuade, Miriam Merad, Fabrice André & Laurence Zitvogel

Bodywide ecological interventions on cancer

Nature medicine

Abstract

Historically, cancer research and therapy have focused on malignant cells and their tumor microenvironment. However, the vascular, lymphatic and nervous systems establish long-range communication between the tumor and the host. This communication is mediated by metabolites generated by the host or the gut microbiota, as well by systemic neuroendocrine, pro-inflammatory and immune circuitries-all of which dictate the trajectory of malignant disease through molecularly defined biological mechanisms. Moreover, aging, co-morbidities and co-medications have a major impact on the development, progression and therapeutic response of patients with cancer. In this Perspective, we advocate for a whole-body ‘ecological’ exploration of malignant disease. We surmise that accumulating knowledge on the intricate relationship between the host and the tumor will shape rational strategies for systemic, bodywide interventions that will eventually improve tumor control, as well as quality of life, in patients with cancer.

Prism center is a one-of-a-kind partnership between

Label

Centre National de Médecine de Précision en Oncologie

Nous contacter

Prism  IHU-B

Bâtiment de médecine moléculaire

32 Rue Camille Desmoulins

94800 Villejuif

Tél. +33(0)1 42 11 00 00

info -at- prism.center

Liens

Presse

Rejoindre nos équipes

Appels à projets

Accessibilité

Les cookies

Mentions légales

Réseaux sociaux